Phenylpropanoids and polyketides
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 25mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 500 MG
Tacrolimus monohydrate (FK506 monohydrate) is a macrocyclic lactone. It binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. It possesses immunosuppressive properties and is intended for research use only.
- Inhibits calcium-dependent events like IL-2 gene transcription, NO synthase activation, cell degranulation, and apoptosis.
- Potentiates actions of glucocorticoids and progesterone by binding to FKBPs.
- May enhance expression of the TGFβ-1 gene.
- Inhibits T cell proliferation in response to T cell receptor ligation.
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 5mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
![Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 5 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661343.jpg-250.jpg)
Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 5 Mg
Tacrolimus (FK 506, also known as Fujimycin) is an immunosuppressant antibiotic used in laboratory and clinical research. This 5mg laboratory-grade quantity is commonly utilized in cell culture studies to investigate immune response modulation, particularly in transplant immunology and autoimmune diseases. Tacrolimus works by inhibiting T-cell activation, making it an essential tool in immunological studies. It is frequently used to understand the mechanisms of immune suppression and to test the effectiveness of other immunosuppressive agents. As a key reagent, tacrolimus plays a critical role in advancing research in immunology and drug development.
Medchemexpress LLC (-)-epigallocatechin gallate | 989-51-5 | MFCD00075940 | 98.1% | C22H18O11 | 10MG
(-)-Epigallocatechin gallate (EGCG) is a flavonoid phenol supplied as a high-purity analytical reference standard for chromatography and mass spectrometry. It is provided as a solid for research applications; users should follow the certificate of analysis for storage and handling.
- Analytical standard for HPLC, GC, and MS method development and quantitation.
- High purity: 98.1% (rounded from COA).
- Chemical formula C22H18O11; molecular weight 458.37 g/mol.
- Available in small package sizes suitable for analytical assays.
- Physical appearance: white to off-white solid.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 10mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
Medchemexpress LLC Trans,trans-2,4-hexadien-1-ol | 17102-64-6 | MFCD00002925 | >=97.0% | 98.14 g/mol | C6H10O | 5 G
(2E,4E)-Hexa-2,4-dien-1-ol (trans,trans-2,4-hexadien-1-ol) is a small unsaturated aliphatic alcohol used as a research reagent and synthetic intermediate. It is commonly supplied stabilized to reduce oxidation and is employed in organic synthesis and analytical applications. Key identifiers include CAS 17102-64-6 and formula C6H10O.
- Unsaturated aliphatic alcohol for organic synthesis and research
- Typically supplied stabilized to limit oxidation
- Typical purity ≥97.0%
- Chemical formula C6H10O; molecular weight 98.14 g/mol
- Suitable for small-scale laboratory and analytical use
Medchemexpress LLC Trans-cinnamaldehyde | 14371-10-9 | MFCD00007000 | 98.0% | 132.16 g/mol | C9H8O | 5 G
trans-Cinnamaldehyde is an aromatic α,β-unsaturated aldehyde used in research and organic synthesis. It functions as a versatile building block for constructing substituted heterocycles, has documented antimicrobial properties, and is reported to modulate TRPA1 in cellular assays. Intended for laboratory use only; handle and store under nitrogen at recommended temperatures.
Medchemexpress LLC Isopropyl benzoate | 939-48-0 | MFCD00048289 | 99.1% | 164.20 g/mol | C10H12O2 | 100 G
Isopropyl benzoate (CAS 939-48-0) is the isopropyl ester of benzoic acid used as an organic reagent, solvent, and intermediate in research, formulation, and fragrance applications. It is supplied for laboratory use with supporting documentation (COA, SDS) and is suitable for synthesis and analytical workflows.
- High purity 99.1%.
- Molecular formula C10H12O2.
- Molar mass 164.20 g/mol.
- Available in multiple pack sizes including 100 g.
- May cause skin sensitization; follow SDS instructions and use appropriate PPE.
Medchemexpress LLC (2E,4E)-hexa-2,4-dien-1-ol | 17102-64-6 | MFCD00002925 | 98.8% | 98.14 g/mol | C6H10O | 1 G
(2E,4E)-Hexa-2,4-dien-1-ol is a small organic compound containing a conjugated diene and a primary alcohol. It is used as a biochemical assay reagent and reference standard in chemical research and flavor/aroma studies. Supplied for research use only.
- High purity (98.81%).
- Molecular formula C6H10O; molecular weight 98.14 g/mol.
- DMSO soluble (200 mg/mL); ultrasonic recommended.
- Appearance: colorless to light yellow; solid below ~28°C, liquid above ~33°C.
- Long-term storage stability: pure form -20°C for up to 3 years.
- COA and SDS available for quality and safety information.
Medchemexpress LLC Coumarin 314 | 55804-66-5 | 250mg
Coumarin 314 is a dye which has an intense absorption in the visible and additionally presents a large solvent dependence[1]
Medchemexpress LLC Isopropyl benzoate | 939-48-0 | MFCD00048289 | 99.1% | 164.20 g/mol | C10H12O2 | 25 G
Isopropyl benzoate (CAS 939-48-0) is an organic ester commonly used as a laboratory reagent and solvent. It is a colorless liquid with formula C10H12O2 and molecular weight 164.20 g/mol, typically supplied at high purity for research and analytical applications.
- High purity (≈99.1%) suitable for analytical and synthetic work.
- Effective organic solvent for reactions and extractions.
- Low odor with good solvency for aromatic compounds.
- Offered in small laboratory packages for convenient handling.
- Stable under normal storage conditions when kept sealed.